By L. Sokoloff (auth.), F. Gonzalez-Lima, Th. Finkenstädt, H. Scheich (eds.)
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Additional info for Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions
1. THEORETICAL BASIS OF RADIOACTIVE DEOXYGLUCOSE METHOD The [14C]deoxyglucose method was designed specifically around the use of the quantitative autoradiographic technique and was based on a kinetic model of the biochemical behavior of 2-deoxyglucose and glucose in brain (Fig. , 1977; Sokoloff, 1982). Both 9 hexoses are transported bi-directionally across the blood-brain barrier by the same carrier and are phosphorylated in the tissues by hexokinase to their hexose-6-phosphate derivatives (Sols and Crape, 1954).
2. Design of Experimental Procedure. The equation in Fig. 6B is obviously too complex to be useful. The experimental procedure was, therefore, designed to simplify the equation as well as to comply better with the assumptions made in its derivation. As with the p4C]deoxyglucose method, administration of the labeled tracer an intravenous pulse followed by a long enough experimental period for the arterial plasma p4C]leucine content (C;) to be cleared by the total body tissues and to fall to very low levels was advantageous.
R; equals rate of glucose utilization; T equals duration of experimental period; A is ratio of distribution space of DG in tissue to that of glucose; ~ equals fraction of G-6-P formed that continues down glycolytic and pentose phosphate shunt pathways (~ = 1 in absence of G-6-Pase activity); and I<:, and V= and K", and Vmare Michaelis-Menten kinetic constants of hexokinase for DG and glucose, respectively. K;', k;, and k; are the rate constants for DG transport and phosphorylation defined in Fig.