Download Analytical and Chromatographic Techniques in by Colin F. Poole, Hal T. Butler, Myra E. Coddens, Sheila A. PDF

By Colin F. Poole, Hal T. Butler, Myra E. Coddens, Sheila A. Schuette (auth.), Donald M. Wieland, Michael C. Tobes, Thomas J. Manger (eds.)

In 1906, Michael T. candy first constructed the chromatographic procedure through the use of an adsorbant to split pigments. in view that that point, the technological advances in TLC and HPLC have caused new definitions of purity in parallel with the advances. Radiopharmaceutical chemistry is principally depending on the chromat­ ographic procedure as a result of quite small volume of fabric in so much radiopharmaceuticals-often so small that the standard actual equipment of analytical chemistry can't be used. for this reason, this number of papers represents the foremost to winning radiopharmaceutical improvement by way of atmosphere the traditional for the pres­ of radiochemical purity. ent-day definition William C. Eckelman, Ph.D. Diagnostics affiliate Director The Squibb Institute for scientific study New Brunswick, New Jersey Preface The chapters herein are up to date and improved models of displays that the authors made at a symposium hung on June four, 1984 in la, California below the sponsorship of the Radiopharmaceutical technological know-how Council of the Society of Nuclear drugs. All manuscripts have been refereed. The purpose of the symposium organizers used to be to enlist contributors who paintings on a daily foundation with the analytical and chromatographic thoughts to be mentioned on the symposium. We consider convinced that this distillation of hands-on event could be of price to graduate scholars in addition to skilled researchers in radio­ pharmaceutical chemistry and comparable fields which use radiotracer methodology.

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Extra resources for Analytical and Chromatographic Techniques in Radiopharmaceutical Chemistry

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8 mm, and wavelength 320 nm (UV) or 430 nm (vis) for azobenzene, and 290 nm and 350 nm (reference) for diphenylacetylene. 1 mg/ml diphenylacetylene. Sample size 200 nl Should be constant when all necessary parameters are controlled; recorder sensitivity at 10 mV peak height (mm) = S m/ x 106 sample weight (ng) g Using all parameters as stated, measure the noise level at a blank area of the plate in the nonscan mode. 1 Azobenzene Diphenylacetylene Standard Concn. 3%) Ave. 3. 3. QUALITATIVE SAMPLE IDENTIFICATION BY HPTLC AND SCANNING DENSITOMETRY Separated sample components are identified in HPTLC by coincidence of their migration properties with standards spotted on the same plate and by measuring the in situ absorption or fluorescence spectra of components for comparison with standard spectra.

Once the scanner has been shown to be working properly, the sample TLC plates are scanned. The ability to do the simultaneous measurement of several labeled 99mTc species in radiopharmaceutical preparations is one of the main advantages of using a radio-TLC procedure in place of an ITLC assay method. 11. General Procedure for Radio-TLC Analysis of 99mTc-Radiopharmaceuticals I. , draw lines at 2 and 12 cm from one edge of the plate for a sample spot at 2 cm from the end of the plate and a lO cm development distance for the sample).

The acetone system for the ITLC-SG assay of 99mTcO,j tends to be erratic and biased high (relative to the MEK system). The problem with acetone is most likely due to the fact that the 99mTc-Iabeled material is highly water soluble in nature (highly polar), and acetone has a higher dielectric constant than MEK and also, generally, has a higher water content than MEK. Another important factor in the use of ITLC is the way in which the sample is developed. For example, if the solvent level in the developing tank is above the level of the applied sample spot on the chromatographic strip, then the solvent becomes contaminated and the results of the analysis will be erroneous.

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