By Robert A. Maes, Hans Brandenberger
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Extra info for Analytical toxicology for clinical, forensic, and pharmaceutical chemists
The above facts show that the clinical laboratory must provide a fast response about the identity and concentration of toxic substances. This is an emergency service which has to operate night and day. Historiocally, forensic chemists were the first to provide this type of service to hospitals. Forensic chemistry, however, differs from clinical chemistry as its results must have legal strength. Confirmation of the results by an independent method is much more important than speed. Today, if a forensic laboratory wants to provide service to a hospital, it should have a special section working on a different basis than the forensic section.
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H. (1956) A method for the simultaneous determination of phenobarbital and diphenylhydantoin in blood. J. Lab. Clin. Med. 47, 649-652. 28. , Svensmark, O. J. (1960) Clinical and electroencephalographic correlations with serum levels of diphenylhydantoin. Arch. Neurol. 2, 624630. 29. Lambie. H. A. (1976) Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy. Lancet 2, 386-389. 30. Lund, L. (1974) Anticonvulsant effect of diphenylhydantoin relative to plasma levels: a prospective three year study in ambulant patients with generalized epileptic seizures.