Download Biologically Active Substances of Protozoa by N.N. Sukhareva-Buell PDF

By N.N. Sukhareva-Buell

The look for new manufacturers of biologically energetic ingredients (BAS) opposed to human and animal ailments remains to be a major job in biology and medication. Experimental paintings has to be performed good previous to desire since it takes a standard of ten years to boost a brand new drugs, in addition to extra time to place it out there. examine of the Protozoa types a unique department of biology - protozoology. the normal fields of protozoology are taxonomy, phylogeny, morphology, cytology, evolution, ecology and host parasite-interactions. The Protozoa is the one taxon one of the microscopic organisms, which has no longer been many times studied as a resource of BAS. This publication then is the results of the study at the undertaking: "Biologically lively elements of the Mastigophora (Flagellates)". The study was once performed on the Laboratory of Antibiotics, division of Microbiology, organic college of Moscow country college. Articles of different authors at the subject were regarded as the $64000 a part of this reference ebook. The aim of the reference booklet is to explain medical methods, which result in acquiring biologically energetic elements from cultures of protozoa; the publication experiences the historic heritage in reference to modern improvement of the sphere. N.N. Sukhareva ACKNOWLEDGMENTS The study used to be played in fruitful cooperation with my learn affiliates (V. Urinyuk, T. Titiova, L. Udalova, R. Zeleneva, V. Brusovanik, M. Zaretskaya), postgraduate scholars (N. Kalenik, M. Chuenkova, V. Vasilevskaya, V. Khorokhorina), my colleagues at Moscow country college (Yu. Kozlov and I.

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Changes in lipid composition of T. , 1997). The change LIPIDS OF FLAGELLATES 31 consists of a rise in the sterol/phospholipid ratio as well as the triacylglyc erol/sterol ether ratio. In addition, the ratio of saturated! , 1997). Work on A. longa showed a reverse change . We focused on the stimulated biosynthesis of polyunsaturated fatty acids of A. longa that was under the influence of active aeration and fatty acid precursors . , 1992). However, media must contain lipid precursors if a producer doesn 't possess the capacity to synthesize them.

A high metabolism was detected due to the action of kinases, phosphomonoesterases, and PI-specific phospholipase C. Often bloodstream trypanosomes depend on the exogenous Iysophospholipids that they may take from a host. A correlation between phosphoinositide metabolism and T. cruzi proliferation in axenic cultures has been found . , 1999). Their results showed differences between T. cruzi and mammalian cells in their respon se to the fluorinated analogues. The authors found that 3-, 5-, and 6-fluoroanalogues did not enter into amastigotes or epimastigotes, but affected the incorporation of inositol into lipids .

1 7. 2 30 CHAPTER 3 The combination of temperature and aeration are key environmental factors, which determine the biosynthesis of polyunsaturated fatty acids . We cultivated A. , 1992). 3). 3. Influence ofvarious tempe ratures ofcultivation on A. 47 4. 62 The total lipid content and quanti tative composinon in flagellates are quite flexible. They depend upon the genetic properties of a species or strain, habitat, or conditions of cultivation. Thus, T. , 1971). , 1971). During aging, the lipid and poly unsaturated fatty acid content of Ochromonas danica significantly increases (Gellerman and Schlenk, 1965; Aaronson and Bensky, 1967) as well as their oxidation in L major (Blum ,1990) .

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